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Debbie et al.<BR>
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Thanks for your reply.<BR>
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You raised some valid points about medical cannabis. I won't go over each point in detail, because some of the problems you raised I think are not central to the debate, and I already addressed some of them, except managing the precise dosage issue, which Health Canada is addressing already, though you suggest because cannabis is a plant this cannot be precise enough.<BR>
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Consider, though, that in the treatment of nausea, or loss of appetite, for example, a patient can use what they need to relieve their nausea, or stimulate their appetite, a dosage that may vary from day to day. This problem is not always as critical as you imply it may be, though I do not mean to minimize it.<BR>
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Of course it would suit the needs of the practice of medicine to have a drug or number of drugs of precise purified dosage that could be delivered to a patient to achieve the benefits of cannabis without the negative side effects. It would be great to have purified drugs of precise dosage that do not have the numerous negative side effects associated with many currently in use in medicine. I already addressed this issue. But you did not make any mention of the central argument for smoked cannabis dealing with the "rapid onset cannabinoid drug delivery" that was mentioned in the NAS report, that cannabis can offer, currently not duplicatable by any other means.<BR>
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Concerning you concerns over precise dosage, consider all the over the counter medications that are not monitored at all by a doctor. I mentioned earlier in a V2020 post that ibuprofen can cause internal bleeding in the digestive track. In fact, if used too much too often, ibuprofen can cause scarring in the digestive track. Let's not broadcast some of these facts too loudly though, because we do not want to interfere with the profits of the pharmaceutical companies, now do we? Further studies are needed of this scaring in the digestive track before we jump to allowing unmonitored use of ibuprofen, don't you think?<BR>
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Also, you mention that morphine has been studied, and state that cannabis has not been studied as completely, which in some respects is a false statement, because cannabis has been studied quite extensively in a variety of ways. If you wish, I can plaster this list with more studies on cannabis regarding a variety of variables than you can read. So far I have only quoted a few government reports dealing with their conclusions regarding the medical applications of cannabis.<BR>
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You want studies relating to cannabis, here we go. What is offered below is only a fraction of what is available in the scientific literature. I think the call for more studies on cannabis from some is disingenuous, a political ploy to delay the application of the evidence for medical cannabis. Kai take note of the first study listed, since he was so concerned with the danger of cannabis use by drivers of motor vehicles. The rest are all just on the immune system effects (first batch), pain relief or the lack thereof effects (second batch) and the last batch deals with cardiovascular effects of cannabis. They are all listings from scientific journals, and if the links are active, you should be able to view every study, unless something goes wrong. They are sourced from a pro-legalization site, so you can inject the suitable skepticism, but the source does not automatically mean there is not vaid science being presented. I don't know if the studies support or deny or are indifferent to medical cannabis, but I offer this listing solely to reflect on the number of studies done on cannabis:<BR>
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<A HREF="http://mojo.calyx.net/~olsen/HEMP/IHA/iha01206.html">http://mojo.calyx.net/~olsen/HEMP/IHA/iha01206.html</A><BR>
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<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Bayewitch%20et.al%2096%20Adenylyl%20Cyclase_%20JBiolChem.pdf">Bayewitch et.al 96 Adenylyl Cyclase_ JBiolChem</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Bouaboula%20et.al%2096%20MAPK%20%26%20KROX-24_%20EurJBiochem.pdf">Bouaboula et.al 96 MAPK & KROX-24_ EurJBiochem</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Burstein%20et.al%2083%20Prostaglandins_%20MolPharmacol.pdf">Burstein et.al 83 Prostaglandins_ MolPharmacol</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Chang%20et.al%2098%20Adenylyl%20Cyclase_%20JPharmExpTher.pdf">Chang et.al 98 Adenylyl Cyclase_ JPharmExpTher</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Childers%20%26%20Deadwyler%2096%20cAMP_%20BiochemPharmacol.pdf">Childers & Deadwyler 96_ BiochemPharmacol</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Condie%20et.al%20%2096%20IL-2_%20JBiolChem.pdf">Condie et.al 96 IL-2_ JBiolChem</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Condie%20et.al%2096%20IL-2_%20JBiolChem.pdf">Condie et.al 96 IL-2_ JBiolChem</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Daaka%20et.al%2097%20IL-2_%20DNACellBiol.pdf">Daaka et.al 97 IL-2_ DNACellBiol</A> <BR>
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<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Greenberg%20%26%20Mellors%2078%20Inhibition%20of%20Acyltransferase_%20BiochemPharmacol.pdf">Greenberg & Mellors 78 Inhibition of Acyltransferase_ BiochemPharmacol</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Herring%20et.al%2098%20cAMP%20%26%20Cannabinol_%20BiochemPharmacol.pdf">Herring et.al 98 cAMP & Cannabinol_ BiochemPharmacol</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Jeon%20et.al%2096%20Nitric%20Oxide_%20MolPharmac.pdf">Jeon et.al 96 Nitric Oxide_ MolPharmac</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Kaminski%2098%20cAMP%20Cascade_%20JNeuroimmunol.pdf">Kaminski 98 cAMP Cascade_ JNeuroimmunol</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Kaminski%20et.al%2092%20Receptor%20Identification_%20MolPharmac.pdf">Kaminski et.al 92 Receptor Identification_ MolPharmac</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Kaminski%20et.al%2094%20Humoral%20Suppression_%20BiochemPharmac.pdf">Kaminski et.al 94 Humoral Suppression_ BiochemPharmac</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Klein%20et.al%2098%20Cytokines_%20DAIA.pdf">Klein et.al 98 Cytokines_ DAIA</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Klein%20et.al%2098%20Receptors%20%26%20Immunity_%20ImmunolToday.pdf">Klein et.al 98 Receptors & Immunity_ ImmunolToday</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Molina-Holgado%20et.al%2098%20IL-6_%20FEBSLett.pdf">Molina-Holgado et.al 98 IL-6_ FEBSLett</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Newton%20et.al%2098%20Cytokine%20Network_%20DAIA.pdf">Newton et.al 98 Cytokine Network_ DAIA</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Noe%20at.al%2098%20Syncytia%20Formation_%20DAIA.pdf">Noe at.al 98 Syncytia Formation_ DAIA</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Ouyang%20et,al%2098%20IL-2_%20MolPharmac.pdf">Ouyang et,al 98 IL-2_ MolPharmac</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Patel%20et.al%2098%20Immuno-%20Reactivity_%20Brain%20Res.pdf">Patel et.al 98 Immuno- Reactivity_ Brain Res</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Poinot-Chazel%20et.al%2096%20KROX-24%20BiochemJ.pdf">Poinot-Chazel et.al 96 KROX-24 BiochemJ</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Sanchez%20et.al%20%2098%20MAPK%20Cascade_%20MolPharmac.pdf">Sanchez et.al 98 MAPK Cascade_ MolPharmac</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Specter%20et.al%2086%20Natural%20Killer%20Cells_%20IntJImmunopharmac.pdf">Specter et.al 86 Natural Killer Cells_ IntJImmunopharmac</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Srivastava%20et.al%2098%20Cytokine%20Production_%20Immunopharmacol.pdf">Srivastava et.al 98 Cytokine Production_ Immunopharmacol</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Stefano%20et.al%2096%20Nitric%20Oxide_%20JBiolChem.pdf">Stefano et.al 96 Nitric Oxide_ JBiolChem</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Zheng%20et.al%2092%20TNF%20alpha%20IntJImmunopharmac.pdf">Zheng et.al 92 TNF alpha IntJImmunopharmac</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Zhu%20et.al%2093%20IL-2_%20IntJImmunopharmac.pdf">Zhu et.al 93 IL-2_ IntJImmunopharmac</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/immune/Zhu%20et.al%2094%20Interleukin%201%20JPharmacolExpTher.pdf">Zhu et.al 94 Interleukin 1 JPharmacolExpTher</A> <BR>
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<P ALIGN=LEFT><BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Bloom%20et.al%2077%20Antinociception%20JPharmExpTher.pdf">Bloom et.al 77 Antinociception JPharmExpTher</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Buxbaum%2072%20Analgesia_%20Psycopharmacalogia.pdf">Buxbaum 72 Analgesia_ Psycopharmacalogia</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Calignano%20et.al%2098%20Pain%20Initiation_%20Nature.pdf">Calignano et.al 98 Pain Initiation_ Nature</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Formukong%20et.al%2088%20Pain%20%26%20Inflammation_%20Inflam.pdf">Formukong et.al 88 Pain & Inflammation_ Inflam</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Herzberg97.pdf">Herzberg97</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Jagger%20et.al%2098%20Pain%20%26%20Inflammation_%20Pain.pdf">Jagger et.al 98 Pain & Inflammation_ Pain</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Kosersky%20et.al%2073%20Pain%20%26%20InflammationEurJPharmac.pdf">Kosersky et.al 73 Pain & InflammationEurJPharmac</A> <BR>
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<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Lichtman%20et.al%2091%20Spinal%20Component_%20BrainRes.pdf">Lichtman et.al 91 Spinal Component_ BrainRes</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Martin%20et.al%2096%20Subthalamic%20Nucleus_%20JNeurosci.pdf">Martin et.al 96 Subthalamic Nucleus_ JNeurosci</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Meng%20et.al%2098%20Analgesic%20Circuit_%20Nature.pdf">Meng et.al 98 Analgesic Circuit_ Nature</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Noyes%20%26%20Baram%2094%20Analgesia_%20ComprPsychiatr.pdf">Noyes & Baram 94 Analgesia_ ComprPsychiatr</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Noyes%20et.al%2075%20Analgesic%20Actions_%20CinPharmacolTher.pdf">Noyes et.al 75 Analgesic Actions_ CinPharmacolTher</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Noyes%20et.al%2075%20Analgesic%20Effect%20JClinPharmac.pdf">Noyes et.al 75 Analgesic Effect JClinPharmac</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Pugh%20et.al%2097%20Dynorphin%20B_%20JPharmExpTher.pdf">Pugh et.al 97 Dynorphin B_ JPharmExpTher</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Richardson%20et.al%2098%20Hyperalgesia%20%26%20Inflammation_%20Pain.pdf">Richardson et.al 98 Hyperalgesia & Inflammation_ Pain</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Richardson%20et.al%2098%20Hyperalgesia_%20JNeurosci.pdf">Richardson et.al 98 Hyperalgesia_ JNeurosci</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Russo%2098%20Migraine_%20Pain.pdf">Russo 98 Migraine_ Pain</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Smith%20et.al%2098%20Arthritis_%20PharmacolBiocemBeh.pdf">Smith et.al 98 Arthritis_ PharmacolBiocemBeh</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Smith%20et.al%2098%20with%20Morphine_%20PharmacolBiochemBeh%20.pdf">Smith et.al 98 with Morphine_ PharmacolBiochemBeh </A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Sofia%20et.al%2073%20Edema%20%26%20Pain_%20JPharmExpTher.pdf">Sofia et.al 73 Edema & Pain_ JPharmExpTher</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Turner%20%26%20Elsohly%2081Cannabichromene_%20JClinPharmacol.pdf">Turner & Elsohly 81Cannabichromene_ JClinPharmacol</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Vivian%20et.al%2098%20Agonists%20%26%20Effects_%20JPharmExpTher.pdf">Vivian et.al 98 Agonists & Effects_ JPharmExpTher</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Welch%20%26%20Stevens%2092%20with%20Morphine_%20JPharmExpTher.pdf">Welch & Stevens 92 with Morphine_ JPharmExpTher</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Welch%20et.al%2095%20with%20Morphine%20JPharmExpTher.pdf">Welch et.al 95 with Morphine JPharmExpTher</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/pain/Yaksh%2081%20Intrathecal%20Administration_%20JClinPharmacol.pdf">Yaksh 81 Intrathecal Administration_ JClinPharmacol</A><BR>
<BR>
<BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/derocq-01.html">Derocq et al., Cell Growth
FEBS Letters. 369(2-3):177-82, 1995 Aug 7</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/derocq-02.html">Derocq et al., Cell Growth
FEBS Letters. 425(3):419-425, 1998 Apr 3</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/fulton-01.html">Fulton & Quilley, Nitric Oxide
Journal of Pharmacology & Experimental Therapeutics. 286(3):1146-1151, 1998 Sep</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/lake-01.html">Lake et al., Cardiovascular Effects
Hypertension. 29:1204-1210, 1997</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/lake-02.html">Lake et al., Hypotension and Bradycardia
Journal of Pharmacology & Experimental Therapeutics. 281(3):1030-1037, 1997 Jun</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/pratt-01.html">Pratt et al., Vascular Relaxation
American Journal of Physiology. 274(1 Pt 2):H375-H381, 1998 Jan</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/randall-01.pdf">Randall & Kendall, Vasoactivity
Trends in Pharmacological Sciences. 19(2):55-8, 1998 Feb</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/stefano-01.html">Stefano et al., Nitric Oxide
The Journal of Biological Chemistry. 271(32):19238-19242, 1996 Aug 9</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/valk-01.html">Valk et al., Growth Factor
Blood. 90(4):1448-57, 1997 Aug 15</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/varga-01.html">Varga et al., Hypotension
The FASEB Journal. 12:1035-1044, 1998</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/wagner-01.html">Wagner et al., During Shock
Journal of Molecular Medicine. 76(12):824-36, 1998 Nov-Dec</A> <BR>
<IMG SRC="http://www.druglibrary.org/crl/images/reddot.gif" WIDTH="14" HEIGHT="14" BORDER="0" DATASIZE="326"> <A HREF="http://www.druglibrary.org/crl/cardiovascular/wagner-02.html">Wagner et al., Vasodilation
Hypertension. 33:429-434, 1999</A> <BR>
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</FONT><FONT COLOR="#000000" BACK="#ffffff" style="BACKGROUND-COLOR: #ffffff" SIZE=2 PTSIZE=10 FAMILY="SANSSERIF" FACE="Arial" LANG="0">I do not understand what was confusing when I mentioned the need for further study of cannabinoids in medicine, as I wrote, "just as there is with many currently available prescribed medicines found on the market." Why is this statement confusing? People die from the effects of legal prescription drugs in some cases because pharmaceutical companies and the medical profession do not study prescription drugs enough, apparently, even when they have been studied extensively enough to justify releasing them onto the market, in the opinion, sometimes economically and politically motivated, of the FDA and the pharmaceutical companies. Continuing to study drugs already on the market can reveal more scientific info about these drugs and their applications, but also can possibly reveal dangerous effects that were not previously uncovered. Anyone who does not believe there are political and profit motives involved in pushing some prescription drugs onto the market for profit rather than health is not paying attention.<BR>
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Your statement that you do not oppose medical use of cannabis seems to be contradicted by many other statements you have made that could lead to the conclusion you think there is not enough study of the issue, or there are too many problems already known, like precise dosage, or negative effects on the immune system, to actually take the step of legalizing cannabis for prescription by doctors.<BR>
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So the next question is, if the Idaho government was to grow standardized cannabis with a known level of cannabinoids, which can be verified by testing, to make legal medical cannabis available for prescription by doctors for those patients the doctors thought, in their medical opinion, could benefit from cannabis, would you approve of this process being legal?<BR>
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If so, you are not against medical cannabis. If not, I suggest you are currently against medical cannabis, regardless of what you say.<BR>
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The answer to the above question cannot be "we need further study" without the unavoidable conclusion that really in the opinion of the respondents view of current knowledge regarding medical cannabis the respondent does not really agree with medical cannabis.<BR>
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Ted Moffett<BR>
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