<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN">
<HTML><HEAD><TITLE>Dr. Murray's Natural Facts</TITLE>
<META http-equiv=Content-Type content="text/html; charset=iso-8859-1"><LINK
href="http://www.doctormurray.com/newsletter/styles.css" rel=stylesheet>
<META content="MSHTML 6.00.2900.2627" name=GENERATOR></HEAD>
<BODY text=#000000 vLink=#663399 aLink=#663399 link=#663399 bgColor=#ffffff
leftMargin=0 background=http://www.doctormurray.com/newsletter/images/bkg.gif
topMargin=0 marginheight="0" marginwidth="0">
<DIV><FONT size=4></FONT> </DIV>
<DIV style="FONT: 10pt arial">----- Original Message -----
<DIV style="BACKGROUND: #e4e4e4; font-color: black"><B>From:</B> <A
title=Newsletter@doctormurray.com
href="mailto:Newsletter@doctormurray.com">Newsletter@doctormurray.com</A> </DIV>
<DIV><B>To:</B> <A title=waf@moscow.com
href="mailto:waf@moscow.com">waf@moscow.com</A> </DIV>
<DIV><B>Sent:</B> Wednesday, April 27, 2005 4:32 PM</DIV>
<DIV><B>Subject:</B> Doctor Murray's Newsletter - Natural Facts For April 27,
2005</DIV></DIV>
<DIV><BR></DIV>
<TABLE cellSpacing=0 cellPadding=0 border=0>
<TBODY>
<TR>
<TD vAlign=top width=100><IMG height=130 alt="Dr. Murray"
src="http://www.doctormurray.com/newsletter/images/photo.jpg"
width=100></TD>
<TD vAlign=top width=550>
<TABLE cellSpacing=0 cellPadding=0 width=550 border=0>
<TBODY>
<TR>
<TD vAlign=top width=550 bgColor=#003300 height=90><IMG height=90
alt="Dr. Murray's Natural Facts"
src="http://www.doctormurray.com/newsletter/images/header.jpg"
width=550></TD></TR>
<TR>
<TD class=mainBODYsmallgreen vAlign=center align=right
height=40>3:05:2005<IMG height=40
src="http://www.doctormurray.com/newsletter/images/spacer.gif"
width=20 align=absMiddle></TD></TR>
<TR>
<TD vAlign=top>
<P class=mainBODYboldgreen>Celadrin for Inflammation</P>
<P><SPAN class=mainBODYboldpurple>Introduction</SPAN></P>
<P>As consumers are searching for alternatives to Vioxx, Celebrex,
and other nonsteroidal anti-inflammatory drugs, one product seems to
be attracting the most attention. This product, Celadrin®, is an
all-natural matrix of special cetylated, esterifed fatty acids. What
this means is that Celadrin® is a mixture of fatty acids that have
been stabilized by attaching natural cetyl alcohol. The specific
components of Celadrin® are cetyl myristoleate, cetyl myristate,
cetyl palmitoleate, cetyl laureate, cetyl palmitate, and cetyl
oleate. <BR>The unique features of Celadrin® as a natural product
include an ability to reduce inflammation and pain quickly with no
side effects as demonstrated in clinical trials published in the
internationally acclaimed Journal of Rheumatology. Available in
cream and capsule form, Celadrin® is clinically proven to produce
results.</P>
<P><SPAN class=mainBODYboldpurple>How does it work?</SPAN></P>
<P>Celadrin® has been shown to impact several key factors that
contribute to inflammation. Its main action appears to be its
ability to enhance cell membrane health and integrity. As a result
it halts the production of inflammatory compounds known as
prostaglandins. It also reduces the production of the negative
immune factors like IL-6 that play a central role in
inflammation.<BR>In simple terms, the bottom line is that Celadrin®
improves the lubrication of joints and prevents the manufacture of
compounds that produce pain and inflammation. </P>
<P><SPAN class=mainBODYboldpurple>What can Celadrin® do for
you?</SPAN></P>
<P>If you suffer from osteoarthritis or other form of arthritis,
Celadrin® can reduce pain and inflammation in affected joints
leading to improved movement. Clinical studies have also shown
Celadrin® to help psoriasis by reducing skin inflammation. <BR>The
reality is that given Celadrin® mechanism of action, it will likely
be shown to be useful in virtually any condition where inflammation
plays a role. In particular, studies are under way to further
document its effect on reducing C-reactive protein – a relatively
recently identified risk factor for atherosclerosis (hardening of
the arteries). Based upon currently available data, Celadrin® is
certainly useful for minor aches and pains associated with simple
backache, arthritis, strains, bruises and sprains. Future studies
will certainly expand this application. </P>
<P><SPAN class=mainBODYboldpurple>What are the results from clinical
studies?</SPAN></P>
<P>The clinical research on Celadrin® has primarily focused on
relief from osteoarthritis. For example, in one of the first studies
sixty-four patients with chronic osteoarthritis of the knee were
evaluated at baseline and at 30 and 68 days after consuming either
placebo or Celadrin®. Results indicated that compared to placebo,
Celadrin® improves knee range of motion and overall joint function.
It was concluded that Celadrin® may be an alternative to the use of
nonsteroidal anti-inflammatory drugs for the treatment of OA.<A
class=mainBODYsmallerpurple href="#ref">1</A></P>
<P>Another study assessed the effect of the Celadrin® cream alone in
osteoarthritis of the knees. Forty patients were randomly assigned
to receive either the Celadrin® cream or a placebo. Patients were
tested on 3 occasions: (1) baseline, (2) 30 min after initial
treatment, and (3) after 30-day treatment of cream application twice
per day. Assessments included knee range of motion, timed
"up-and-go" from a chair and stair climbing, and two other
functional tests. For stair climbing ability and the up-and-go test,
significant decreases in time were observed 30 minutes after the
first administration and after one month of use only in the
Celadrin® group. Likewise, range of motion of the knees increased
with Celadrin® both 30 minutes after the initial application and
after one month’s use. In contrast, no difference was observed in
the placebo group. The other functional tests also clearly
demonstrated improvements with Celadrin® while the placebo failed to
produce results.<A class=mainBODYsmallerpurple href="#ref">2</A></P>
<P>In one of the latest studies with Celadrin® in patients with knee
osteoarthritis, patients were assessed by having them stand on a
special platform for 20 and 40 seconds to measure static postural
stability (the ability to stand comfortably in one place for a
period of time). Again, only those subjects using the Celadrin®
cream demonstrated improvements.<A class=mainBODYsmallerpurple
href="#ref">3</A></P>
<P>One of the key points to make here with Celadrin® is that unlike
many other natural approaches it produces almost immediate
results.</P>
<P><SPAN class=mainBODYboldpurple>Answers to common
questions</SPAN></P>
<P><EM>Can Celadrin® be used with glucosamine sulfate and other
natural approaches for osteoarthritis?</EM> Absolutely, Celadrin®
unique mechanisms of action complement any natural or drug therapy
for osteoarthritis safely and without side effect.<BR><BR><EM>How
does Celadrin® compare to CMO (cetylmyristoleate)?</EM> CMO is
simply one of the components of the unique matrix of Celadrin®.
Researchers discovered the mixture was more effective than the
isolated CMO. Hence, Celadrin® can be simply regarded as an enhanced
form of CMO.<BR><BR><EM>What is the proper dosage?</EM> Celadrin®
cream can be applied to affected areas on an as needed basis. The
dosage with oral preparations is three capsules daily.<BR>Is there
any difference between the various oral forms of Celadrin®? The
product is available in tablets, soft gelatin, and hard gelatin
capsules. Since Celadrin® is a fatty acid complex, softgel capsules
may provide advantages in absorption, just as with other
lipid-loving molecues (e.g. CoQ10). As well, the published clinical
trials utilized Celadrin® in a softgel form. Therefore, I strongly
recommend using Celadrin® in softgel capsules.<BR><BR><EM>Is any
form of Celadrin® cream better than another?</EM> Yes, be sure that
the cream that you are using is free from parabens, pthalates, and
other harmful ingredients. Parabens are widely used as preservatives
in food, cosmetics, and topical joint care products. There have been
recent studies indicating that parabens in cosmetic products and
underarm deodorants may be a factor in the increasing numbers of
women developing breast cancer. Natural Factors has recently
introduced a paraben-free Celadrin® cream.<BR><BR><EM>Is Celadrin®
safe?</EM> The safety profile is exceptional with no reported side
effects or drug interactions. Celadrin® definitely does not have any
of the side effects associated with anti-inflammatory drugs such as
Steroids, NSAIDS (e.g. aspirin), and COX 2 inhibitors (e.g. Vioxx,
Celebrex). <BR><BR><EM>Can Celadrin® be used on a long-term
basis?</EM> Absolutely, Celadrin® is completely safe for indefinite
use without side effect.<BR><BR><EM>Are there any interactions with
prescription drugs?</EM> There is no indication or known mechanism
where Celadrin® would cause an adverse interaction with any
medication. </P>
<P><SPAN class=mainBODYboldpurple>Final comment</SPAN></P>
<P>There is an old saying that makes great sense in this day and age
– <SPAN class=mainBODYboldgreen>NEVER TAKE A DRUG THAT PRODUCES SIDE
EFFECTS MORE SEVERE THAN THE DISEASE!</SPAN> That is certainly the
case when we look at drugs used to treat the most common form of
arthritis – osteoarthritis. No one has ever died from
osteoarthritis, but serious adverse side effects (including death)
can occur with conventional drugs used for this condition.
Fortunately, nature offers some very effective alternatives.<BR></P>
<P class=mainBODYboldpurple><STRONG><A name=Ref></A>References
</STRONG></P>
<DIV class=mainBODYsmaller>
<P>1. Hesslink R Jr, Armstrong D 3rd, Nagendran MV, Sreevatsan S,
Barathur R. Cetylated fatty acids improve knee function in patients
with osteoarthritis. J Rheumatol. 2002;29(8):1708-12. <BR><BR>2.
Kraemer WJ, Ratamess NA, Anderson JM, et al. Effect of a cetylated
fatty acid topical cream on functional mobility and quality of life
of patients with osteoarthritis. J Rheumatol.
2004;31(4):767-74.<BR><BR>3. Kraemer WJ, Ratamess NA, Maresh CM, et
al. Effects of treatment with a cetylated fatty acid topical cream
on static postural stability and plantar pressure distribution in
patients with knee osteoarthritis. J Strength Cond Res.
2005;19(1):115-21.<BR><BR>4. Darbre PD, Aljarrah A, Miller WR, et
al. Concentrations of parabens in human breast tumours. J Appl
Toxicol. 2004;24(1):5-13. </P>
<P> </P>
<P class=mainBODYboldgreen> </P>
<HR align=center width="100%" noShade SIZE=1>
© 2005 www.doctormurray.com</DIV></TD></TR></TBODY></TABLE></TD>
<TD vAlign=top width=419>
<TABLE height=90 cellSpacing=0 cellPadding=0 width="100%" border=0>
<TBODY>
<TR>
<TD
bgColor=#003300> </TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></BODY></HTML>